CAS 54965-24-1 Tamoxifen citrate 100% Customs Clearnace

CAS NO 54965-24-1
Molecular Formula C32H37NO8
Molecular Weight 563.64
Melting point 140-144 °C
Boiling Point 665.9 °C at 760 mmHg
Appearance powder
Storage 2-8°C
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CAS 54965-24-1 Tamoxifen citrate in stock 100% Customs Clearnace
Product Description
Product Name Tamoxifen citrate
Synonyms TomixipheneCitrate; TAMOXIFENCITRATE,USP; TAMOXIFEN CITRATE ANTI-ESTROGEN, PROTEI; (Z)-[2-[4-(1,2-diphenylbut-1-enyl)phenoxy]ethyl]dimethylammonium dihydrogen 2-hydroxypropane-1,2,3-tricarboxylate; (Z)-1-(4-Dimethylaminoethoxyphenyl)-1,2-diphenyl-1-butene Citrate;
CAS NO 54965-24-1
Molecular Formula C32H37NO8
Molecular Weight 563.64
Melting point 140-144 °C
Boiling Point 665.9 °C at 760 mmHg
Flash Point 356.5 °C
Solubility methanol: soluble50mg/mL, clear, colorless
Appearance powder
Storage 2-8°C
Payment Western union, Bitcoin, XMR, USDT, TT
Delivery By sea, by air, all express modes (EMS,UPS,DHL,TNT,Fedex), 3-5 days after payment
Shipping adress Provide your valid and correct destination address info with post office code, phone number and consignee
Package Choose the most appropriate way according to quantity and safety degree
CAS 54965-24-1 Description

It’s an orally active, selective estrogen receptor modulator (SERM) which blocks estrogen action in breast cells and can activate estrogen activity in other cells, such as bone, liver, and uterine cells.Tamoxifen Citrate is a potent Hsp90 activator and enhances the Hsp90 molecular chaperone ATPase activity. Tamoxifen Citrate also potent inhibits infectious EBOV Zaire and Marburg (MARV) with IC50 of 0.1 µM and 1.8 µM, respectively. Tamoxifen Citrate activates autophagy and induces apoptosis.Tamoxifen Citrate also can induce gene knockout of CreER(T2) transgenic mouse.

Scientific Background

Endocrine therapy for the treatment of breast cancer. It interrupts estrogen signaling by blocking the estrogen receptor (ER). In vivo, tamoxifen and tamoxifen metabolites bind to the estrogen receptor, resulting in inhibition of transcription of estrogen-responsive genes. In vitro, tamoxifen is known to inhibit protein kinase C through estrogen receptor-independent antitumor effects. Therefore, this drug has important applications in breast cancer research, especially in ER+ breast cancer. Recent studies have shown that tamoxifen-resistant cells use autophagy as a survival mechanism.

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