URB-597 CAS 546141-08-6

URB-597 CAS 546141-08-6

URB-597 | FAAH inhibitor

CAS: 546141-08-6
Activity: FAAH inhibitor
Chemical Name: Cyclohexylcarbamic acid 3′-(aminocarbonyl)-[1,1′-biphenyl]-3-yl ester
Molecular Weight: 338.41
Molecular Formula: C20H22N2O3
Solubility: Soluble in DMSO (up to 15 mg/ml).
Physical Properties: Off-white solid
Purity: 98% by TLC NMR (Conforms)
Storage Temperature: RT
Stability: Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20° for up to 3 months.
Shipping Code: RT

 

URB-597 (546141-08-6) is a potent and selective fatty acid amide hydrolase (FAAH) inhibitor, IC50 = 3-5 nM.1 Produces cannabinoid CB1 and CB2 receptor-mediated analgesia in inflammatory pain states without causing side effects associated with cannabinoid receptor activation.2 Attenuates the anxiolytic-like effect of acetaminophen in a mouse model.3 Exerts anti-inflammatory effects in rat hippocampus and ameliorates age-related deficits.4 Off target effects of URB-597: Reduces tyrosine hydroxylase expression.5 Improves cognitive impairment caused by chronic cerebral hypoperfusion in a mouse model via inhibition of mTOR-dependent autophagy.6

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